The application of lightweight Large Language Models in rule-based scientific domains remains severely limited by their tendency to mimic linguistic patterns rather than reproduce axiomatic reasoning, causing frequent hallucinations. Here, we show that G-Frame, an adaptive multi-agent framework integrating Bayesian and team game principles, establishes an automated closed-loop for high-quality data synthesis and model training. By forcing the internalization of domain constraints through structured reasoning, we synthesized a specialized corpus of 363,045 chains-of-thought and 199,589 question-answer pairs. The resulting 7B model OmniChem achieves performance parity with GPT 4o mini on custom benchmarks and ChemBench while exhibiting a 79.46% reduction in hallucinations relative to its base architecture. We further demonstrate the advanced capabilities of OmniChem in molecular design and synthesis planning. This work establishes a scalable paradigm utilizing adaptive multi-agents to overcome inherent reasoning deficiencies, offering a feasible pathway for accelerating knowledge discovery in specialized scientific fields.
Runzhe Liu, Biquan Bie, Zihao Wang et al.· 0 citations
The effectiveness of modern visual representation learning and autoregressive models critically depends on vector quantization (VQ), which discretizes continuous feature representations using a learnable codebook. Despite its widespread use, existing VQ methods often suffer from training instability and codebook collapse, arising from gradient mismatch induced by the straight-through estimator and the under-utilization of code vectors. In this work, we show that both issues can be traced to a fundamental mismatch between the distributions of feature vectors and code vectors, leading to inefficient representation and information loss. Building on this observation, we propose a distributional matching framework for vector quantization. We introduce principled criteria for desirable VQ behavior and demonstrate through theoretical analysis and empirical evaluation that aligning feature and code vector distributions provides a unifying mechanism for mitigating training instability and codebook collapse. We instantiate this framework using a Wasserstein-based objective with an efficient closed-form under a mild Gaussian approximation, and further show that a nonparametric alternative based on maximum mean discrepancy yields comparable performance. Extensive experiments on visual tokenization benchmarks support the effectiveness and robustness of the proposed approach.
Xia Fang, Litao Guo, Hengchao Chen et al.· 0 citations
