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Author

Yi-Bin Liu

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Sep 2026

Genome-Wide Detection of DNA Lesions at Single-Base Resolution Using Glycosylase-Cleavage Ligation-Assisted Sequencing

Upon exposure to endogenous and exogenous damaging agents, tens of thousands of DNA lesions are generated in the mammalian genome, including uracil (U), 8-oxo-7,8-dihydroguanine (8OG), and apurinic/apyrimidinic (AP) sites. It has been documented that these lesions can impair genomic integrity by inducing single-stran...

Neng-Bin Xie, Tong-Tong Ji, Yong Zhu et al. · 0 citations
Open access Sep 2026

Genome-wide cell-free DNA methylation profiling via TAPS for moyamoya disease diagnosis and postoperative collateral formation prediction.

Moyamoya disease (MMD) lacks reliable biomarkers for distinguishing it from atherosclerotic cerebrovascular disease (ACVD) and predicting postoperative collateral formation (PCF). Here, we apply low-input, bisulfite-free TET-assisted pyridine borane sequencing to plasma cell-free DNA (cfDNA) from 39 MMD and 37 ACVD pat...

Tong-Tong Chen, Ze-Tian Jia, Ying Tang et al. · 0 citations

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