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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Yi-Bo Chang

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Open access Sep 2026

Development of m6A Readers for Enhanced Recognition In Vitro via Genetic Code Expansion

The YTH domain was recently demonstrated as a promising tool for recognizing and regulating m6A-modified RNAs. However, the deficiency in binding affinity (micromolar range) and selectivity (off-target binding) for m6A of the wild-type YTH domain limit its sensitivity and accuracy for m6A recognition. Engineering strat...

Michael S. Addo, Elise D. Ficaretta, Yi-Bo Chang et al. · 0 citations

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