Route-Dependent Behavioral, Dopaminergic, and Transcriptomic Adaptations to Nicotine Aerosol Inhalation and Systemic Injection in Male Mice.
Nicotine is one of the most widely used psychoactive substances, yet most preclinical studies rely on subcutaneous injection, which does not fully model inhalation-based exposure. How different nicotine delivery paradigms shape neurobehavioral adaptations remains unclear. Here, we compared subcutaneous nicotine injecti...