Author

Yi-Chen Zhou

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Review Open access Oct 2026

Deep brain stimulation and spinal cord stimulation for chronic disorders of consciousness: a decade of clinical evidence, mechanistic insights, and critical appraisal

Deep brain stimulation (DBS) and spinal cord stimulation (SCS) have been investigated for over four decades as neuromodulatory treatments for chronic disorders of consciousness (DOC), including the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and the minimally conscious state (MCS), for which no disease-...

Dong-Sheng Liu, Kai-Wai Yang, Jian-Lei An et al. · Frontiers in Human Neuroscie... · 0 citations

Review Open access Sep 2026

Neural Circuit Mechanisms of Disorders of Consciousness and Potential Therapeutic Targets of Brain Stimulation

ABSTRACT Background Disorders of consciousness (DoC) lack an integrated framework to guide neuromodulation. This review updates three hierarchical frameworks—ARAS, mesocircuit, and ICNs—and maps therapeutic targets within each. Methods We synthesized recent neuroanatomical, optogenetic, neuroimaging, and clinical trial...

Yi-Chen Zhou, Tian-Qing Cao, Si-Peng Zhu et al. · CNS Neuroscience & Therapeut... · 0 citations