Author

Yi-Cun Han

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Review Sep 2026

Metabolic reprogramming of myeloid antigen-presenting cells in the tumor microenvironment: mechanisms of antigen presentation failure and therapeutic opportunities.

Antigen-presenting cells (APCs) translate tumor-derived signals into adaptive immune responses, yet their function is shaped by the metabolically hostile tumor microenvironment (TME). Hypoxia, acidosis, nutrient scarcity, and immunoregulatory metabolite accumulation can reprogram myeloid APC metabolism, impair antigen...

Pei-Shan Zhou, Yi-Cun Han, Qing Ji · Biochimica et biophysica act... · 0 citations

Open access Aug 2026

Bioinformatics analysis and experimental validation of EOMES expression and correlation with exhausted CD8+ T cell in colorectal cancer

Colorectal cancer (CRC) ranks among the most prevalent malignancies globally, yet exhibits limited responsiveness to immunotherapy. This therapeutic challenge stems primarily from incomplete understanding of immune microenvironment regulation in CRC. Although Eomesodermin (EOMES) has been implicated in tumor immune che...

Yu Tang, Jian-Ying Gu, Yong-Qi Chen et al. · Discover Oncology · 0 citations