Author

Yi-Fan Cheng

2 papers indexed here

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Open access Aug 2026

ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

ATP-dependent chromatin remodeling enzymes play central roles in genome regulation by mobilizing nucleosomes. All remodelers except for one, position their core ATPase at an internal nucleosome location, superhelical location (SHL) 2, and translocate DNA from this site to alter nucleosome conformation. The exception, t...

Hao Wu, Upneet Kaur, Cheng-Min Li et al. · bioRxiv · 0 citations

Aug 2026

Substrate Mimicry by Inhibitors of the Mycobacterium tuberculosis 20S Proteasome and Their Activity against Mycobacteria In Vitro and in Macrophages

The remarkable and problematic capacity of Mycobacterium tuberculosis to persist in the host is dependent on a functional 20S proteasome that is structurally and functionally analogous to its mammalian counterpart. It has been proposed that this enzyme is critical for the bacterium’s adaptive response to a variety of...

Xilin Gu, Peter J. Rowheder, Zanlin Yu et al. · ACS Chemical Biology · 0 citations