Carbenylative Buchwald-Hartwig Coupling of Aryl Halides, N-Tosylhydrazones, and Anilines
A Pd/Cu cocatalyzed synthesis of N-benzhydryl amines from aryl halides (electrophiles), N-tosylhydrazones (carbene equivalents), and anilines (nucleophiles) has been developed. The reaction operates under mild conditions and exhibits broad substrate scope and excellent functional group tolerance. The synthetic utility...