Cisplatin response in gastric cancer is shaped by malignant cell programs, stromal states, and mutation‐immune crosstalk, but the CAF subtypes linked to platinum tolerance and their epithelial effectors remain incompletely defined. We integrated single‐cell RNA sequencing, epithelial CNV‐like inference, fibroblast recl...
Deyi Lu, Fanlai Meng, Weiying Zhou et al.· Human Mutation· 0 citations
Background Lymphangiogenesis promotes tumor dissemination and may shape the immune contexture of cervical cancer, yet lymphangiogenesis-related prognostic stratification and its immunometabolic implications remain insufficiently defined in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Methods...
Xi-Jing Fan, L. Chen, Jing Xu et al.· Frontiers in Genetics· 0 citations
MFAP2 is a hub SRIG linking eCAFs, ECM remodeling, and immune escape in GC, which serves as a reliable prognostic and ICI resistance predictor and potential therapeutic target, providing a basis for precision therapy in GC.