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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Yi-Fei Wang

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Aug 2026

Perillaldehyde alleviates Parkinson's disease via the gut microbiota-5-methyltetrahydrofolate-homocysteine methylation axis.

BACKGROUND Gut microbiota dysbiosis is critically involved in the pathogenesis of Parkinson's disease (PD), yet therapeutic strategies targeting the gut-brain axis remain underexplored. Perillaldehyde (PAH), a natural monoterpene aldehyde primarily extracted from Perilla frutescens, exhibits significant neuroprotective...

Xiyu Gao, Aohan Yan, Yi-Fei Wang et al. · 0 citations
Open access Aug 2026

Combined hydrogen and oxygen therapy attenuates vascular cognitive impairment in rats via gut microbiota-derived SCFA-GPR41/PI3K/Akt/Nrf2 signaling

It is found that HHOS significantly improved spatial memory and reduced anxiety-like behaviors in BCCAO rats, and outperformed monotherapies by coupling microbiota-SCFA restoration with GPR41/PI3K/Akt/Nrf2-mediated antioxidant defense, supporting a novel dual-gas strategy for VCI.

Xin-Lei Fu, Meng-Zhuo Ma, Yujing Zhang et al. · 0 citations

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