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Author

Yi-Feng Xu

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Open access Sep 2026

Tandem RNA-binding domain architecture drives PKR activation through an intramolecular interface.

Tandem repeats of RNA-binding domains (RBDs), often linked by intrinsically disordered sequences, are prevalent among RNA-binding proteins (RBPs). The inherent flexibility of these arrangements, however, raises the question of whether such domains can adopt defined configurations critical for function. Here, we reveal...

Chong Han, Chen Li, Yi-Feng Xu et al. · 0 citations
Open access Sep 2026

Identification of Two Novel Compound Heterozygous ADAMTS17 Variants Associated With Weill-Marchesani Syndrome 4.

PURPOSE Weill-Marchesani syndrome 4 (WMS4) is frequently underdiagnosed when standard exome sequencing fails to detect noncoding pathogenic variants. We aimed to identify the genetic cause in a patient with suspected WMS4 and to characterize the splicing-altering mechanism of a deep intronic variant in ADAMTS17. MATE...

Wen-Jing Ku, Yi-Feng Xu, S. Jiao et al. · 0 citations

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