Author

Yi-He Yang

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Open access Aug 2026

Partitioned blood pressure polygenic risk reveals differential genetic effects of tissue-specific enhancers and their interactions on cardiovascular disease

Polygenic risk scores (PRS) compress genome-wide associations into a single predictor, but this aggregation obscures the distinct biological mechanisms through which genetic variation shapes complex traits. Here we introduce a framework that additively decomposes a trait’s PRS, without loss of SNP heritability, into in...

Xiao-Feng Zhu, Yi-He Yang, Dongwon Lee et al. · Research Square · 0 citations

Aug 2026

AI Challenges and the Future of Education: A Needed Epistemic, Political, and Ecological Agenda for Critical Leadership Scholars and Practitioners

Artificial intelligence is already transforming contemporary education. Besides revolutionizing how students learn and educators teach it is also challenging the frameworks of knowledge and power that underpin leadership. Unfortunately, and because of an imposed discourse of urgency spread from big AI corporations and...

Antonio Jiménez-Luque, Yi-He Yang · New Directions for Student L... · 0 citations

Open access Sep 2026

Privacy-Aware Distillation of Large Language Models for Enhanced Multimorbidity Scoring

This work introduces and evaluates a privacy-preserving knowledge distillation framework for LLM-based clinical modeling, using multimorbidity scoring as a healthcare task, and establishes a trustworthy, privacy-compliant pathway for large-scale healthcare applications of LLMs.

R. Awasthi, Yi-He Yang, Meng-Xuan Li et al. · medRxiv · 0 citations