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Yi-Hsun Chan

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Review Open access Sep 2026

507. Ketamine use disorder following intranasal esketamine for treatment-resistant depression: a case report and literature review

Abstract Background Esketamine, the S-enantiomer of ketamine, is an NMDA receptor antagonist approved for treatment-resistant depression (TRD). Although regulated clinical trials suggest a low risk of misuse, concerns remain that esketamine exposure may facilitate transition to ketamine dependence, particularly in East...

Yi-Hsun Chan, H.-M. Chang · 0 citations

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