BeyondTACs: Chemical Editing of Posttranslational Modifications (PTMs) for Therapeutic Intervention.
Protein posttranslational modifications (PTMs) build up the diversity and complexity of the proteome, and their dysregulation is intrinsically linked to various diseases. The study of PTMs has profoundly broadened the scope of therapeutic target discovery. Building upon the success of PROTACs, this heterobifunctional p...