Review
Aug 2026
Mechanism of neoantigen generation and advances in neoantigen-based immunotherapies in colorectal cancer
This review outlines the molecular mechanisms driving neoantigen generation in CRC, including frameshift mutations, single-nucleotide variants, alternative RNA splicing, and circular RNA-derived epitopes, and evaluates neoantigen-directed therapeutic platforms, encompassing personalized neoantigen vaccines and adoptive T-cell therapies that are engineered to recognize neoantigen-derived epitopes.
Na Wang, Yi-Meng Xia, Ping Wang et al.
· Medical Oncology · 0 citations