Review
Open access
Sep 2026
Immune-neural crosstalk in chronic low back pain: from intervertebral disc degeneration to pain sensitization
Chronic low back pain (CLBP) is a leading cause of disability, yet radiographic degeneration correlates poorly with symptoms. This mini-review examines how immune-neural crosstalk may link intervertebral disc degeneration to pain initiation and persistence. Degenerated nucleus pulposus and annulus fibrosus cells develo...
Jin-Jin Wei, Zhi-Yun Guan, Yao-Bin Long et al.
· Frontiers in Immunology · 0 citations