Author

Yi-Jing Su

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#diffusion models Review Open access Oct 2026

Estrogen and Alzheimer’s Disease: Neurobiology, Epigenetics, and AI-Driven Therapeutic Design

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and women are disproportionately affected. This review examines the evidence that estrogen signaling contributes to this disparity and asks what a molecularly targeted therapeutic would require. We first distinguish prevalence from incidence in the g...

Tian-Hua Zhai, Risa Garg, Pei-Ming Li et al. · Journal of Dementia and Alzh... · 0 citations

Open access Aug 2026

Spatial mapping of RNA turnover kinetics in the mouse brain.

Gene regulation requires coordinated control of RNA synthesis and degradation, yet measuring RNA turnover across intact tissues remains challenging. Here we present spatial NT-seq, a method that combines transgenesis-free metabolic RNA labeling with in situ chemical recoding on spatial transcriptomics platforms to co-m...

Q. Qiu, Hongjie Zhang, Zi-Jie Xia et al. · Nature Neuroscience · 0 citations