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Yi-Jun Chen

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Open access Sep 2026

Demethylzeylasteral Targets the Sp1/AGAP2 Axis to Impair Autophagic Flux and Induce Apoptosis in Hepatic Stellate Cells.

BACKGROUND AND AIM Chronic liver injury-induced liver fibrosis, if left untreated, can progress to cirrhosis or hepatocellular carcinoma, posing a serious threat to human health. Our previous study demonstrated that the natural product demethylzeylasteral (T-96) alleviates liver fibrosis by suppressing ArfGAP with GTPa...

Cheng-Long Wu, Jie Gao, Bo Gao et al. · 0 citations

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