Tumor microenvironment-responsive size-switchable nanoplatforms integrating focused ultrasound achieve highly efficient synergistic chemo-starvation antitumor therapy.
Insufficient intratumoral accumulation and penetration remain major barriers that limit the therapeutic efficacy of nanotechnology-based drug delivery systems (NDDSs). Herein, tumor microenvironment-responsive size-switchable carrier-free nanoplatforms (GMFD NPs) are constructed using glucose oxidase (GOD), Fe3+, MnO2...