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Yi-Lin Chen

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Open access Sep 2026

ORAI Ca2+ Channels and STIM1 Drive Capillary-to-Arteriole Communication in Neurovascular Coupling

Neurovascular coupling (NVC), initiated by the brain’s dense capillary network, matches blood flow to neuronal activity, yet key underlying mechanisms remain unresolved. We found that ORAI1 channels and their regulator STIM1, the main drivers of store-operated Ca2+ entry, are essential for communicating neuronal metabo...

Boris Lavanderos, Alfredo Sanchez-Solano, Wan-Chun Zhu et al. · 1 citation

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