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Open access Oct 2026

The lysine acetyltransferase Rv0998 coordinates transcriptional and metabolic adaptation of Mycobacterium tuberculosis to acidic pH

ABSTRACT Mycobacterium tuberculosis (Mtb) survives host defenses by adapting to host conditions, including acid stress, during infection. A critical survival strategy involves pH homeostasis, mediated by complex signaling systems that regulate metabolic reprogramming and stress responses. While the lysine acetyltransfe...

Yi Liu, Nadia Fernandes, Valwynne Faulkner et al. · 0 citations
Open access Sep 2026

Rv3400 is a phosphoglucomutase required for trehalose metabolism in Mycobacterium tuberculosis

ABSTRACT Mycobacterium tuberculosis (Mtb) causes over 1 million deaths from tuberculosis (TB) every year and remains a major burden on human health. Reducing the deadly impact of TB requires a better understanding of the strategies used by M. tuberculosis to adapt its metabolism, survive, and persist in the human host....

Yi Liu, Nadine Ruecker, Valwynne Faulkner et al. · 0 citations

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