This study discovered that dioscin extended the lifespan of Caenorhabditis elegans and significantly reduced expression of senescence markers (p21, p16) in hepatic and skeletal muscle tissues.
Yi Luo, Nian Jiang, Xiao-Cong Li et al.· Experimental Gerontology· 0 citations
BACKGROUND
Liver fibrosis (LF) lacks effective therapies. Longevity assurance homolog 2 (LASS2), a key ceramide synthase, contributes to liver homeostasis, but its role in LF remain unclear.
METHODS
Bioinformatics revealed LASS2 correlation with classic fibrotic factors, and its expression was assessed in fibrotic mo...
Exposure to PM2.5 significantly elevated the levels of several testicular proteins, including NLRP3, ASC, cleaved caspase-1, cleaved caspase-1, cleaved caspase-3, GSDMD-N, total caspase-1, and full-length GSDMD, whereas cleaved caspase-3 did not differ significantly.
Yi Luo, Cao Wang, Meng-Xi Tian et al.· PLoS ONE· 0 citations
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