Background Bispecific antibodies (bsAbs) have rapidly emerged as one of the most promising therapeutic strategies in oncology because of their ability to simultaneously engage multiple molecular targets and enhance antitumor immunity. Although the number of publications has increased substantially, a comprehensive bibl...
Xiao-Tian Zhai, Z. Rong, Li-Xia Fu et al.· Frontiers in Immunology· 0 citations
Liver sinusoidal endothelial cells (LSECs) form a specialized discontinuous microvascular interface between sinusoidal blood and the hepatic parenchyma. Functioning as a central regulator of hepatic homeostasis, LSECs integrate metabolic, inflammatory, and hemodynamic signals to maintain sinusoidal permeability, immune...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic interstitial pneumonia of unknown etiology, in which macrophages serve as central orchestrators of the pathological microenvironment. During IPF progression, the alveolar macrophage pool undergoes a critical compositional shift: tissue-resident alve...
Guang-Yan Mu, Shan Chong, Jiu-Long Li et al.· Frontiers in Immunology· 0 citations
AIMS
Aildenafil citrate, an orally bioavailable phosphodiesterase type 5 (PDE5) inhibitor, is primarily metabolized by cytochrome P450 3A4 (CYP3A4). This study aimed to assess potential pharmacokinetic interactions between aildenafil citrate tablets and cytochrome P450 (CYP)3A modulators.
METHODS
This study involved...
Ran Xie, Nan Zhao, B. Jia et al.· British Journal of Clinical...· 0 citations
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