Author

Yi-Min Zhang

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Open access Jan 2026

Dissection of Microglial Heterogeneity and Identification of Pain‐Related Subpopulations After Traumatic Brain Injury

Background Pain following traumatic brain injury (TBI) is a major challenge in clinical management. Neuroinflammatory responses, particularly those involving microglia, are increasingly implicated in the synaptic and circuit‐level remodeling associated with post‐TBI pain. However, the conventional M1/M2 framework does...

Fu Zhao, Jing-Ru Shi, Yi-Min Zhang et al. · Pain Research and Management · 0 citations

Aug 2026

Single-cell reanalysis characterizes an Osmr+ astrocyte state and predicts midkine signaling to Cox6b1+ glutamatergic neurons at 24 h after traumatic brain injury.

BACKGROUND Traumatic brain injury (TBI) remains a leading cause of mortality and long-term neurological disability worldwide. The cellular heterogeneity and intercellular communication in the injured brain remain incompletely defined, particularly the astrocyte-neuron crosstalk that could drive potential interventions....

Fu Zhao, Lu-Xi Cao, Jia-Nan Chen et al. · Brain Research · 0 citations

Yi-Min Zhang

Dissection of Microglial Heterogeneity and Identification of Pain‐Related Subpopulations After Traumatic Brain Injury

Single-cell reanalysis characterizes an Osmr+ astrocyte state and predicts midkine signaling to Cox6b1+ glutamatergic neurons at 24 h after traumatic brain injury.

Single-cell reanalysis characterizes an Osmr+ astrocyte state and predicts midkine signaling to Cox6b1+ glutamatergic neurons at 24 h after traumatic brain injury.