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Yi-Ming Chen

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Open access Jul 2026

A pooled CRISPR-based neuronal activity screen links TMEM50A-dependent MVB function to synaptic integrity and remote memory.

A high-throughput functional genomics platform that couples the calcium-integrating sensor CaMPARI2 with CRISPRi screening in human iPSC-derived neurons is established and reveals a critical role for TMEM50A-dependent MVB function in maintaining synaptic integrity and behavior.

Jian-Hui Wang, Meiqi Liu, Yi-Ming Chen et al. · 0 citations

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