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Author

Yi-Nuo Wang

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Sep 2026

PRMT1 and YBX1 Cooperatively Transcriptionally Activate GPX4 to Inhibit Ferroptosis and Promote Breast Cancer Progression.

Ferroptosis, a regulated form of cell death driven by lipid peroxide accumulation, is crucial in tumor development and controlled by Glutathione Peroxidase 4 (GPX4). Targeting ferroptosis offers a promising cancer therapy approach but remains challenging. Here we show that Protein Arginine Methyltransferase 1 (PRMT1) i...

Yu Li, Bao-Wen Yuan, Jia-Xiang Liu et al. · 0 citations
Jul 2026

FABP5 attenuates pulmonary fibrosis by regulating lipid metabolism in type II alveolar epithelial cells.

It is found that FABP5 expression was significantly downregulated in AT2 cells from IPF patients and bleomycin-induced models, and FABP5 mitigated bleomycin-induced lung fibrosis by increasing global lipid and medium/long-chain fatty acid levels.

Hang Yin, Zhixiang Lei, Yuqi Mai et al. · 1 citation
Review Jul 2026

The cardiac 4D nucleome: nuclear and chromatin dynamics across development, disease and ageing.

The nucleus is a highly organized and dynamic organelle, with hierarchical layers ranging from nucleosome positioning to chromatin domains and higher-order 3D genome topology, and this organization enables precise and context-dependent transcriptional control.

Yi-Nuo Wang, G. Dobreva · 1 citation

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