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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Yi-Ping Liu

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Oct 2026

A PTC-catalyzed diastereoselective Mannich reaction to access indanone-based α-amino acid derivatives.

We herein disclose a phase-transfer-catalyzed diastereoselective Mannich reaction between β,γ-alkynyl-α-ketimines and in situ generated 1-hydroxy isobenzofulvene anions from 2-alkylidene-1-indanones, enabling the formation of indanone-based α-amino acid derivatives with good results (up to 93% yield with >20 : 1 dr in...

Lei Yang, Yue-Shan Hou, Wan-Yu Wei et al. · 0 citations
Sep 2026

Enantioselective (3+2) Cycloaddition–Rearrangement Strategy to Access Benzo[ d ]isothiazole‐Containing Polyheterocycles

Benzo[ d ]isothiazole motif has emerged as a privileged structure in medicinal chemistry and agricultural science. However, conventional synthetic methods are plagued by tedious multistep procedures, low atom economy and harsh reaction conditions, rendering the development of a facile and convenient approach for...

Hui-Ling Qian, Wen-Tao Gao, Min Liao et al. · 1 citation

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