Yi-Qing Chen

Fab Dimerization Crosslinks and Activates the γδ T-Cell Receptor

The gamma delta T-cell receptor (γδ TCR) mediates γδ T-cell responses that are crucial for immune defense, tissue surveillance, and homeostasis. While recent studies suggest that γδ TCRs engage ligands multivalently, how multivalent engagement activates the γδ TCR remains elusive. Here, we present the structures of the...