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Author

Yi-Qing Zheng

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Sep 2026

Development of a subunit vaccine candidate (RBD-HA trimer) provides dual protection against multi-subtype avian influenza viruses and QX-type infectious bronchitis virus.

Avian influenza virus (AIV) and infectious bronchitis virus (IBV) are major respiratory pathogens of poultry, and their co-circulation complicates disease control. Here, we developed a chimeric subunit vaccine, RBD-HA, in which the receptor-binding domain (RBD) of the QX-type IBV spike protein replaced the immunodomina...

Yi-Qing Zheng, Bing-Chen Qiao, Zi-He Gao et al. · 0 citations
Sep 2026

Transcriptome screening identifies circRNA-INSR as a novel host factor associated with avian influenza virus replication.

Circular RNAs (circRNAs) represent a class of covalently closed non-coding RNA molecules that exert vital regulatory effects on host-pathogen interplay. The H9N2 subtype of avian influenza virus (AIV) is a widespread pathogen on a global scale, inflicting considerable economic damage to the poultry sector and harboring...

Zhi-Yuan Liu, Meng-Lu Fan, Yi-Qing Zheng et al. · 0 citations
Open access Jul 2026

LncRNA ckATP1A1-AS1 inhibits influenza A virus replication by mediating innate immune responses and suppressing viral nuclear import

These findings establish ckATP1A1-AS1 as a key antiviral lncRNA that restricts IAV replication by coordinating innate immune signaling and directly targeting several steps in the viral replication cycle.

Meng-Lu Fan, Zhi-Yuan Liu, Lu-Lu Deng et al. · 0 citations

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