Author

Yi-Quan Chen

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Open access Sep 2026

Cornea-Penetrating Nanodrug Co-Delivering VEGF-Silencing siRNA and Lutein for Treating Age-Related Macular Degeneration.

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness among the elderly, driven by oxidative stress, chronic inflammation, and pathological choroidal neovascularization (CNV). Although intravitreal anti-vascular endothelial growth factor (VEGF) therapies remain the current clinical stand...

Yong Li, Fan Xiao, Zi-Wei Liu et al. · Advances in Materials · 0 citations

Open access Aug 2026

ACE2-PNA conjugates exploit viral endocytosis for targeted intracellular delivery and exhibit dual antiviral efficacy against SARS-CoV-2

A Receptor-Drug Conjugate (RDC) strategy, in which a therapeutic payload is covalently linked to a decoy receptor, enabling virus-triggered targeted intracellular delivery, and has significant implications for reducing off-target toxicity and enhancing antiviral potency.

Yi-Fei Wang, Jing-Han Xu, Yi-Quan Chen et al. · Molecular Biomedicine · 0 citations