MAPT (Tau) dysregulation is implicated in several neurodegenerative diseases, but its contribution to amyotrophic lateral sclerosis (ALS) is poorly understood. Here we show that mRNA isoforms encoding 4-repeat (4R) Tau are upregulated and cytoplasmically enriched in iPSC-derived motor neurons (MNs) from VCP-mutant and...
H. Crerar, Michele Stasi, Koustav Pal et al.· bioRxiv· 0 citations
Biofilm-associated functional amyloids reinforce extracellular matrices and enhance microbial resistance to environmental and antimicrobial stresses. In Staphylococcus aureus, phenol-soluble modulins (PSMs), particularly the PSM-α family, regulate biofilm maturation and pathogenicity through sequence-dependent self-ass...
Feng-Juan Huang, Yi-Ran Wang, Hao Sun et al.· Colloids and Surfaces B: Bio...· 0 citations
A role for IR is emerging in both health and neurodegenerative diseases, including amyotrophic lateral sclerosis, and its potential as a therapeutic target is highlighted, as well as how IRTs may influence subcellular localization of ribonucleoprotein complexes, loss of function of bound RNA binding proteins (RBPs) and...
Chloe Y Wang, Stephanie Taylor, Virenkumar A Pandya et al.· Brain : a journal of neurolo...· 0 citations
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