A Hydrophilicity-Switchable, Self-Immobilizing Near-Infrared Photosensitizer for γ-Glutamyltransferase-Activated Precision Photodynamic Therapy.
Photodynamic therapy (PDT) is a minimally invasive cancer treatment, but its clinical translation is limited by the intrinsic conflict between hydrophilicity for systemic delivery and hydrophobicity for cellular uptake and retention. Here, we report a γ-glutamyltransferase (GGT)-activatable, hydrophilicity-switchable,...