Yi-Ruo Zhang

Integrative analysis of single-cell and bulk RNA sequencing reveals inflammatory mechanisms of cancer-induced nerve injury and enables prognostic modeling in lung adenocarcinoma.

BACKGROUND Cancer-induced nerve injury (CINI) is implicated in unfavorable clinical outcomes across multiple cancer types. However, its biological role and prognostic value remain insufficiently characterized in lung adenocarcinoma (LUAD). METHODS Bulk RNA sequencing, single-cell RNA sequencing, and spatial transcrip...