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Review Open access Sep 2026

Space radiation health risks to hematopoietic, neural, and gastrointestinal systems in astronauts

The rapid progress in global deep space exploration presents astronauts with a complex space radiation environment that substantially exceeds that of near-Earth orbit. Space radiation primarily consists of galactic cosmic rays (GCRs) and solar particle events (SPEs), which exhibit strong penetrative capability and cons...

Long-Zhen Zhang, Yi-Shu Yin, Run-Ze Li et al. · 0 citations
Open access Aug 2026

A Ternary Flavonoid Formulation Mitigates Fractional Radiation-Induced Brain Injury via Transcriptomic Reprogramming and Synaptic Protection

Fractional ionizing radiation (FIR) is a standard cancer therapy but often induces severe central nervous system complications, including cognitive decline and physiological dysfunction. While natural flavonoids hold therapeutic promise for radiation-induced brain injury (RIBI), optimizing their combinations and elucid...

Yuan-Bing Zhu, Yi-Shu Yin, Ting Ju et al. · 0 citations
Open access Sep 2026

Proton Radiation-Induced Cognitive Impairment via Disruption of Hippocampal Neuronal Mitophagic Homeostasis

Background: Proton radiation is both a core component of the space radiation environment and a pivotal modality for precision clinical tumor radiotherapy. Proton exposure can impair cognitive, learning and memory functions, representing a common concern in the fields of deep space aerospace medicine and clinical radiot...

Long-Zhen Zhang, Pu Chen, Nan Xu et al. · 0 citations
Review Open access Jul 2026

Effects of plant-derived polysaccharides on intestinal barrier function, immunomodulation, and gut microbiota: mechanisms and research advances

This paper critically elucidates how monosaccharide composition, molecular weight, glycosidic bonds, and chemical modifications determine biological activity and proposes an integrated ‘crop-to-clinical’ perspective that links agricultural sourcing, processing stability, and clinical validation.

Ting Ju, Yi-Shu Yin, Jia-Yu Wang et al. · 0 citations

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