Open access
Sep 2026
Spatial partitioning of NSD2 defines H3K36me2 as an active mark for repetitive sequence activation
Histone H3 lysine 36 dimethylation (H3K36me2) plays a key role in transcriptional elongation and chromatin organization, yet how its deposition is spatially controlled across the genome remains unclear. Here, we identify TOP1 as a critical recruiter of the H3K36me2 methyltransferase NSD2 to gene bodies. Disruption of t...
Jun-Qi Jia, Yu Liu, Jia-Min Yu et al.
· Nature Communications · 0 citations