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Yi Ting Zhou

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Open access Aug 2026

Systematic evaluation of spatial transcriptomic annotation methods reveals conserved tumor microenvironment programs in NSCLC

Introduction Spatial transcriptomics (ST) enables high-resolution mapping of cellular heterogeneity in tumor microenvironments, but downstream cell-type annotation remains highly method-dependent. Methods Here, we systematically evaluated four representative annotation frameworks—Seurat, CARD, RCTD, and SPOTlight—acros...

Mingke Wu, Yi Ting Zhou, Ding-Jie Xu · 0 citations

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