Yi-Tong Shen

Peli1 promotes sepsis-induced inflammation and coagulopathy by maintaining lipg stability in macrophages.

Sepsis is marked by dysregulated inflammation and coagulopathy, with macrophages playing a central role. However, the molecular mechanisms linking macrophage dysfunction to sepsis-associated coagulopathy remain unclear. This study investigated the role of the E3 ubiquitin ligase Peli1 in sepsis progression and its down...