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Open access Sep 2026

Elevated Plasma DISC1 Levels Are Associated With Motivational Deficits in Medication‐Free Patients With Major Depressive Disorder: An Exploratory Study

ABSTRACT Disrupted‐in‐Schizophrenia 1 (DISC1) has been implicated in major psychiatric disorders, but the relationship between circulating DISC1 protein and dimensional motivation and pleasure‐related features in major depressive disorder (MDD) is unknown. This exploratory cross‐sectional study compared plasma DISC1 le...

Zhen-Hua Zhu, Xu-Yuan Yin, Jia Huang et al. · 0 citations
Aug 2026

Machine learning classification of schizophrenia and social anhedonia based on facial expressions.

BACKGROUND AND HYPOTHESIS Schizophrenia (SCZ) is characterized by deficits in emotional expression, with facial expressions serving as potential markers for diagnosis. Leveraging machine learning and computerized facial analysis, this study aimed to identify facial expression features in patients with SCZ and individua...

Li-ying Zhang, Ji-Wei Nie, Mei Liu et al. · 0 citations

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