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Yi-Wei Chang

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Open access Oct 2026

A conserved GTPase complex gates exocytosis for defence and parasitism across alveolates.

Regulated protein secretion is a fundamental process by which eukaryotic cells respond to and interact with their dynamic environments, yet its mechanism outside metazoans remains largely unknown. Here we uncover an atypical small GTPase complex (Nd-GTPase-Nd9-NdP1) conserved across the Alveolata-a major eukaryotic cla...

M. Cova, Lucas Morley, Marjorie Maynadier et al. · 0 citations
Open access Aug 2026

Repositioning of polyubiquitin alters the pathologic tau filament structure.

It is found that polyubiquitinated tau filaments from Alzheimer disease and vacuolar tauopathy human brain tissue exhibit distinct seeding patterns in mice, in association with differences in tau filament ultrastructure determined by cryo-electron microscopy.

Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich et al. · 1 citation

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