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Yi-Wen Zha

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Open access Sep 2026

Hypertriglyceridemia and atherosclerosis in Apolipoprotein A5 mutant rabbits generated using CRISPR/Cas9.

ApolipoproteinA5 (APOA5) plays an important role in regulating plasma triglycerides (TG). Most in vivo data, however, derive from murine models whose lipoprotein metabolism diverges substantially from humans, and no rabbit APOA5 loss-of-function model has previously been described. Microinjection of Cas9 mRNA and two e...

Yi-Wen Zha, Lin-Ling Feng, Ting Zhang et al. · 0 citations

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