Author

Yixin Zhao

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Aug 2026

Metabolic Vulnerability Indices and Alzheimer's Disease Risk: A Prospective Analysis of the UK Biobank Cohort.

BACKGROUND Metabolic dysfunction is implicated in Alzheimer's disease (AD) pathogenesis. Branched-chain amino acids (BCAAs) have been prospectively linked to dementia risk, yet prospective associations of composite metabolic vulnerability indices with incident AD remain untested. OBJECTIVE To examine associations of...

Guan-Ran Ding, Yuting Liu, Yi-Xin Zhao et al. · Journal of NutriLife · 0 citations

Open access Sep 2026

Ultra-processed food consumption and atherosclerosis risk: a prospective cohort study of UK Biobank

Ultra-processed foods (UPFs) have become dominant in modern diets, yet their relationship with atherosclerosis—the primary pathological basis of cardiovascular disease—remains inadequately characterized. We investigated the association between UPF consumption and incident atherosclerosis risk and explored underlyin...

Yi-Xin Zhao, Yu-Guang Li, Xiang-Liang Liu et al. · Frontiers in Nutrition · 0 citations

Review Aug 2026

The ER stress-autophagy axis in cancer-induced muscle wasting: Unveiling the IRE1α/XBP1 pathway as a therapeutic target.

This review examines how tumor-derived signals activate IRE1α/XBP1 to upregulate both the autophagy-lysosome pathway (ALP) and ubiquitin-proteasome system (UPS); its crosstalk with inflammatory and metabolic networks; and the therapeutic potential of IRE1α inhibitors, XBP1-directed strategies, and nutritional approache...

Guan-Ran Ding, Wang Yang, Yi-Xin Zhao et al. · Biochimica et biophysica act... · 0 citations