Open access
Jul 2026
KCNE2 upregulation improves cardiac function by inhibiting Smurf1-mediated SERCA2a degradation in diabetic cardiomyopathy in mice
A novel protective role of KCNE2 is revealed in diabetic hearts and upregulation is proposed as a potential therapeutic strategy for DCM by suppressing Smurf1-mediated polyubiquitination and proteasomal degradation of SERCA2a.
Ming Song, Kai-Ping Gao, Jie Yang et al.
· Acta Pharmacologica Sinica · 0 citations