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Yixin Zhuge

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Open access Jul 2026

KCNE2 upregulation improves cardiac function by inhibiting Smurf1-mediated SERCA2a degradation in diabetic cardiomyopathy in mice

A novel protective role of KCNE2 is revealed in diabetic hearts and upregulation is proposed as a potential therapeutic strategy for DCM by suppressing Smurf1-mediated polyubiquitination and proteasomal degradation of SERCA2a.

Ming Song, Kai-Ping Gao, Jie Yang et al. · 0 citations

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