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Author

Yi-Yuan Wang

2 papers indexed here

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Review Aug 2026

AKAP12 as a signal-compartmentalizing Hub across diseases: Context-dependent functions and translational potential.

A-kinase anchoring protein 12 (AKAP12; Gravin/SSeCKS) is a multidomain scaffold that coordinates spatially restricted signaling rather than acting as a single linear effector. By organizing protein kinase A (PKA), protein kinase C (PKC), phosphodiesterases (PDEs), proto-oncogenic non-receptor tyrosine kinase (Src)-rela...

Jiao Tian, Yuyuan Lu, Tao Wu et al. · 0 citations
Review Open access Sep 2026

Cell-state- and compartment-dependent PI3K/Akt redox signaling in chronic kidney disease: mechanisms and translational implications

Chronic kidney disease (CKD) progression results from coordinated pathological processes across diverse renal cell types and cannot be reduced to extracellular matrix accumulation alone. Tubular stress, disruption of the glomerular filtration barrier, microvascular rarefaction, immune activation, and interstitial remod...

Jian-Zong Xuan, Ren-Hua Ding, Hai-Ying Zhang et al. · 0 citations

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