Exploring the Mechanism of DEHP Promoting Hepatic Fibrosis Based on Network Toxicology by Triggering Lipophagy-Dependent Hepatic Stellate Cell Activation
Di(2-ethylhexyl)phthalate (DEHP), a common environmental endocrine disruptor and agricultural organic pollutant, has drawn wide concern for its hepatotoxicity. However, the molecular mechanisms underlying DEHP-induced hepatic fibrosis remain unclear. Through network toxicology analysis, lipid metabolism and autophagy...