Yi-Zhou Wang

CCT2 expression marks a translation-activated state in sporadic ALS motor neurons and is associated with functional decline

Sporadic disease accounts for about 90% of amyotrophic lateral sclerosis (ALS) cases, and its biological heterogeneity is a major contributor to the failure of trials that enroll patients under a single diagnosis. Because sporadic ALS lacks a shared genetic anchor, identifying biological signals is critical for effecti...