Open access
Oct 2026
Dynamics of human cardiogenesis and its disruption in trisomy 21.
Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches1. Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a context-aware, resolution-agnostic niche classificat...
J. Cranley, Kazumasa Kanemaru, S. Bayraktar et al.
· Nature · 0 citations