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Author

Yicong Pan

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Open access Aug 2026

Spatial multi‐omics unveils sphingolipid metabolic reprogramming within the retinal pathological niche

It is revealed that spatially defined immunometabolic remodeling—in which Trem2 + microglia are central—converges on sphingolipid metabolism as a druggable regulatory axis, with the TREM2‐SPTLC2 interface thus emerging as a new therapeutic opportunity for retinal neurodegenerative diseases.

Yun-Hong Shi, Jinpei Lin, Yi Wu et al. · 0 citations
Review Open access Sep 2026

Targeting ferroptosis in ocular diseases: mechanisms, clinical implications, and therapeutic horizons.

Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has been increasingly implicated in selected ocular diseases, although its causal relevance varies across disease entities. The retina and retinal pigment epithelium are biologically susceptible to ferroptosis-related injury becau...

Naiyuan Zhang, Huiqian Kong, Yu-Heng Liao et al. · 0 citations

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