Plastics have become an integral part of our modern society, largely because they are generally regarded as chemically inert under normal circumstances. However, plastics fragmented into microplastics (less than 5 mm in size) have recently raised significant public concerns, and have been detected widely across ecosyst...
These findings establish antibiotic-driven phase separation as a previously unrecognized mechanism to encode cellular signaling and identify antibiotic condensates as a distinct functional unit underlying drug tolerance.
Yuefeng Ma, Wen Yu, E. Moon et al.· bioRxiv· 0 citations
Biomolecular condensates, which regulate diverse cellular processes, exhibit distinct electric potential profiles. This potential gradient between the dilute and the dense phases serves as the underlying driving force mediating the unique microenvironment and electrochemical activity of condensates. However, the molecu...
Fangke Chen, Runchen Xia, Yi-Fan Dai et al.· bioRxiv· 0 citations
This chapter describes synthetic gene circuit-based methods for applying synthetic condensates in E. coli to regulate transcription and translation and demonstrates how engineering synthetic condensates offers a new layer of cellular control for synthetic biology.
