Author

Yifan J. Li

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Open access Jul 2026

Unmasking Supervillin: SVIL haploinsufficiency causes hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics

SVIL-associated cardiomyopathy is established as a mechanistically distinct form of HCM and drugs targeting mitochondrial bioenergetics may be a therapeutic strategy in patients with SVIL-associated cardiomyopathy.

Yifan J. Li, Y. Psaras, V. Steeples et al. · bioRxiv · 0 citations

Jul 2026

METTL3‐Activated IDO1‐Kynurenine Pathway in Insulin‐Producing Cells Enhances Graft Survival and Attenuates Endogenous Islet Apoptosis in Diabetic Mice

It is shown that METTL3 overexpression is associated with IDO1 upregulation and elevated systemic Kyn levels, which suggest that the METTL3‐IDO1‐Kyn pathway may be a potential target for improving cell replacement therapy for diabetes.

Shan Xu, Li-Xuan Fang, Jia-Jun Qiu et al. · The FASEB Journal · 0 citations