Yifan Zhou

ZEB1 directly activates IL-6 to promote triple-negative breast cancer stemness in an epigenetically constrained context

ZEB1 is a key driver of breast cancer pathogenesis and therapy resistance, largely through its ability to promote cancer stem cells (CSCs). Although tumor-secreted cytokines such as IL-6 are known to support tumor progression, how their expression is regulated by upstream transcriptional factors such as ZEB1 remains in...